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The reason people take 1000x plus etc is often due to absorption issue. Many people have problems absorbing B12. That's why they have a deficiency to begin wi
by 13years 9y ago
The reason people take 1000x plus etc is often due to absorption issue.
Many people have problems absorbing B12. That's why they have a deficiency to begin with. In order for these people to get normal B12, it requires extreme doses just for their bodies to absorb normal amounts.
- myth_drannon 9y agoYeah, the older you get the more likely you going to get absorption issues.
- phyzome 9y agoIt's not just that -- there's an active and a passive pathway for absorption. The active pathway is limited to 1-2 µg per day by the quantity of "intrinsic factor" produced by the stomach even for people with no absorption disorder, but about 1% of oral B-12 can be absorbed through passive diffusion. If you're trying to remediate a deficiency, intramsucular shots or high oral doses are the correct approach. I think there's another limitation in how much the liver can capture and process per day, and I don't know what that limit is, but it's higher. In any event, once it is processed (and after excess is eliminated), it is highly conserved in your body -- a few micrograms can last years, IIRC.