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> they modified the CRISPR associated DNA editing enzyme, cas9 This is incorrect. They modified a separate enzyme that is fused to cas9.
by 88e282102ae2e5b 9y ago
> they modified the CRISPR associated DNA editing enzyme, cas9
This is incorrect. They modified a separate enzyme that is fused to cas9.
- deleted 9y ago[deleted]
- evincarofautumn 9y agoI think that’s what they meant, and said. Cas9 “CRISPR associated protein 9” is the protein/enzyme that they modified.
- 88e282102ae2e5b 9y agoI'm definitely getting into hair-splitting territory, but I think it's important to not conflate modifying a protein with fusing two proteins. It would be easy to come away from the GP and think that scientists have the ability to easily change the enzymatic function of Cas9, when in reality they're effectively just connecting a protein to Cas9 and letting it do its thing.
- evincarofautumn 9y agoAh, I see what you’re getting at. I agree.