Another hiring manager here who reads GitHub profiles and loves to have a candidate walk me through what challenges they experienced, design decisions they had

Another hiring manager here who reads GitHub profiles and loves to have a candidate walk me through what challenges they experienced, design decisions they had to make, etc. One question I have for the grandparent post: what would a meaningful question be? Is the description I mention above seem like a meaningful way to discuss the work you took the time to share with me?