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Neat. I've been fasting for an average of 6 days at a time, once-a-month. It's hell for the first 3 days but it gets better. Related but different, perhaps som

Neat. I've been fasting for an average of 6 days at a time, once-a-month. It's hell for the first 3 days but it gets better. Related but different, perhaps someone with a bio/med background knows: Regarding the metformin FDA Phase 4 clinical trial for life extension and a conflicting recommendation from my PCP that metformin (1500 mg) has a significant risk of injury from acute hypoglycemia in those (like yours truly) without type-2 diabetes but being overweight (about 20%). I didn't see anything in the literature or box warnings about common hypoglycemia risks, especially in good liver & kidney functional patients, and the body can regulate glucose with a panoply of pathways. Seems to me, metformin looks like it has massive potential to benefit many people to up-regulate healthy pathways, but only if doctors understood its limitations and capabilities in settings outside of diabetes. Or am I missing or wrong about something? https://clinicaltrials.gov/ct2/show/NCT02432287 https://clinicaltrials.gov/ct2/show/NCT02432287 https://www.webmd.com/drugs/2/drug-11285-7061/metformin-oral/metformin-oral/details/list-sideeffects https://www.webmd.com/drugs/2/drug-11285-7061/metformin-oral... https://www.drugs.com/sfx/metformin-side-effects.html https://www.drugs.com/sfx/metformin-side-effects.html

sudshekhar 9y ago
> I've been fasting for an average of 6 days at a time, once-a-month. Can you explain your process more? Do you hold not eat for 18 or so hours for those 6 days?
- burntrelish1273 9y ago
  Just water often and electrolytes (Ca, Na, Mg, K) as needed. I've been testing fish oil to convince the gallbladder to empty because developing gallstones doesn't sound fun. Background: I'm currently about 35 lbs. / 16 kg. overweight, which was partially medication-contributed but I also picked up the proverbial fork, and now I'm just not very hungry.
YeGoblynQueenne 9y ago
Out of curiousity, how did you choose your regimen? It does sound very hard to follow. I fast every other day (the EODF method the paper studied). It's actually surprisingly easy and from what I can tell from the (no more than a dozen) sources I've read it's just as effective as longer-term fasts. I've been at it since July, with two weekly breaks basically. I was also overweight before starting. My BMI went from 26.3 to 24.2 since then, something I had been trying to achieve for at least a couple of years, with no success. I'd also be interested to hear from someone with a medical or biological background. I'm particularly interested in the effects of fasting on blood pressure and kidneys. I have an older relative who is a kidney patient and overweight which probably contributes to their high blood pressure and it'd be great if I could recommend they follow my diet.
- burntrelish1273 9y ago
  Yeah, I was 28.5, currently 26.9 and aiming for 20.

sudshekhar 9y ago

> I've been fasting for an average of 6 days at a time, once-a-month. Can you explain your process more? Do you hold not eat for 18 or so hours for those 6 days?

burntrelish1273 9y ago
Just water often and electrolytes (Ca, Na, Mg, K) as needed. I've been testing fish oil to convince the gallbladder to empty because developing gallstones doesn't sound fun. Background: I'm currently about 35 lbs. / 16 kg. overweight, which was partially medication-contributed but I also picked up the proverbial fork, and now I'm just not very hungry.

YeGoblynQueenne 9y ago

Out of curiousity, how did you choose your regimen? It does sound very hard to follow. I fast every other day (the EODF method the paper studied). It's actually surprisingly easy and from what I can tell from the (no more than a dozen) sources I've read it's just as effective as longer-term fasts. I've been at it since July, with two weekly breaks basically. I was also overweight before starting. My BMI went from 26.3 to 24.2 since then, something I had been trying to achieve for at least a couple of years, with no success. I'd also be interested to hear from someone with a medical or biological background. I'm particularly interested in the effects of fasting on blood pressure and kidneys. I have an older relative who is a kidney patient and overweight which probably contributes to their high blood pressure and it'd be great if I could recommend they follow my diet.

burntrelish1273 9y ago
Yeah, I was 28.5, currently 26.9 and aiming for 20.