> with .1% of the characters randomly changed Nope, not randomly. Having a random error profile is the best case. In reality these machines suffer from systema

> with .1% of the characters randomly changed Nope, not randomly. Having a random error profile is the best case. In reality these machines suffer from systematic errors, especially the Illumina ones. That means that they always fail to read through certain pieces of DNA, or make the same error every time.