5 ms·
Most estimates I'm familiar with are substantially lower than that - between 0.1 and 3 errors per cell division.
by chrisamiller 9y ago
Most estimates I'm familiar with are substantially lower than that - between 0.1 and 3 errors per cell division.
- nonbel 9y agoThanks, actually the wikipedia link was "per generation" and they assume ~ 100 divisions/mitoses per human generation. So it should be 1e-10 mutations/bp/division. However, that is for germline, somatic mutation rates are apparently 10-100x more more common: https://www.nature.com/articles/ncomms15183 https://www.nature.com/articles/ncomms15183 These rates no doubt vary by cell type, environment, etc. I was actually thinking something like 1e-6 to 1e-10 mutations/bp/division.