there is no specific, canonical sequence at large scales, neither between two individuals nor even two cells This is correct, and is a reason why genome inform

there is no specific, canonical sequence at large scales, neither between two individuals nor even two cells This is correct, and is a reason why genome informatics has been moving away from representing the genome as a single linear "reference" sequence of 3 billion nucleotides, and towards a graph-based model: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411762/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411762/.