Haven't paid attention to this area in a while but back in the day I've wondered about the garbage-in garbage-out problem in genome databases. A lot of subseque

Haven't paid attention to this area in a while but back in the day I've wondered about the garbage-in garbage-out problem in genome databases. A lot of subsequent sequence assemblies were made on the basis of approximate matching to certain results in the database that have no quality information, and conclusions made on the basis of further approximate matching across datasets. Has anyone seriously worked out how reliable some of these conclusions are? At least physicists spend a lot of time worrying about p-values.