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I've done work in statistical genetics, but not in forensic analysis specifically, so take these rough estimates with a grain of salt. That said, forensic analy
by AlexCoventry 9y ago
I've done work in statistical genetics, but not in forensic analysis specifically, so take these rough estimates with a grain of salt. That said, forensic analysis generally involves identifying the origin of a tissue sample. If the sample is substantial enough for reliable genotyping, once the genotyping is done the actual identification step should take less than a second in a well-optimized system, even to pick out the origin from every human genome in history (assuming such a database was available.) It's just a matter of finding who has matching allelic variants, and ensuring that you match over enough common alleles with low linkage disequilibrium (shared-haplotype correlation) that the risk of a match is infinitesimal, even among individuals with high consanguinity. If you organized the genomes in a tree where each node split on a single allele, you could search in logarithmic time.
- woodson 9y agoThe situation is more difficult if you consider the possibility of having multiple contributors to a sample (mixtures), allele dropout, etc. I’ve heard some models/implementations take a day for MCMC sampling to calculate the probabilities. (I’m talking about forensic DNA specifically)