I agree... at some point, when analyzing a topic, we need to prune the decision tree leading to some tentative conclusions, even if some subtrees might not be 1

I agree... at some point, when analyzing a topic, we need to prune the decision tree leading to some tentative conclusions, even if some subtrees might not be 100% verifiably invalid. Our science is imperfect, reporting is imperfect, and very few (if any) complete-information scenarios exist.