The biggest development in single-molecule sequencing (aside from the steady improvement in PacBio's methods) is the arrival of the Oxford Nanopore devices on t

The biggest development in single-molecule sequencing (aside from the steady improvement in PacBio's methods) is the arrival of the Oxford Nanopore devices on the market. These are also pretty rough around the edges, but they suggest a future in which labs have direct access to long-read, low-cost sequencing. Also, techniques like that from 10X genomics allow large-scale haplotype resolution, which is another missing component of a true "whole genome" sequence (humans and many other creatures have more than one different genome copy).