> In almost all psilocybin studies, the effect is mediated by the degree to which the participant has a 'mystical-type experience.' > I don't imagine this coul

> In almost all psilocybin studies, the effect is mediated by the degree to which the participant has a 'mystical-type experience.' > I don't imagine this could be experienced while unconscious, and so assuming that's correct, then it would be substantially less effective if someone was unconscious. It's correlation, but to determine causation one would have to undergo simultaneous mystical-inducing-quantity psilocybin and be "naturally" unconscious (because e.g. stuff used for general anesthesia is likely to interfere with other brain processes). I have no idea how such an experiment could actually be carried out.