I think it mostly comes down to user experience. The best user experience is usually going to be specifically tailored to an individual application. It won't be

I think it mostly comes down to user experience. The best user experience is usually going to be specifically tailored to an individual application. It won't be very generalizable. Apps created with ui builders (or even with just a constrained set of ui components like bootstrap) tend not to have good ux since every workflow has to be shoehorned into an existing abstraction. It's convenient for the programmer (and the budget), but not for the user.