I asked myself that question about a year ago. What I did was go play around with the tutorials at todomvc.com to get a feel for what was out there. When I was

I asked myself that question about a year ago. What I did was go play around with the tutorials at todomvc.com to get a feel for what was out there. When I was done I couldn't really decide what was best and after straining over that for a few weeks I finally decided to look at what was "easiest" (for me) instead. That allowed me to look at it an entirely new way. That was a question that I could answer. I ended up choosing PouchDB/jQuery/Bootstrap. Those tools provide an amazing feature rich set of APIs that work together seamlessly and all have great community support. From there I can look for smaller libraries of code that focus on a specific task and drop them in too. Once I got started with them I was amazed at how productive I was. It's easy (for me) to get things done using those tools.