As for fMRI, while it's not particularly under existential threat re:empiricism, it's not necessarily a silver bullet: http://blog.brainfacts.org/2016/07/are-fm

As for fMRI, while it's not particularly under existential threat re:empiricism, it's not necessarily a silver bullet: http://blog.brainfacts.org/2016/07/are-fmri-data-analysis-methods-reliable/ http://blog.brainfacts.org/2016/07/are-fmri-data-analysis-me... Personally, my opinion is that the ambiguity of people's self-perceptions of their persona allows there to be an asymmetry between the harm they might get receiving advice about their personality and the benefit they might get from heeding advice about personalities that they can at least envision themselves as being perceived by others as having, if that makes sense. It probably isn't particularly empirical, but I don't know if we will get to a science of personality within our lifetimes (but (maybe..?) it would be nice to be proved wrong).