In addition, this doesn't really prove that the "simulation" can't use extremely aggressive "level of detail" culling, only simulating such intensive things lik

In addition, this doesn't really prove that the "simulation" can't use extremely aggressive "level of detail" culling, only simulating such intensive things like the quantum Hall effect when it directly effects the events of the simulation, or when a particularly curious simulatee decides to measure it. When the simulation can afford to gloss over such intensive details, it could use some much less expensive approximation, and we would never be any wiser. Same thing with the uncertainty principle: electrons are only an approximation until we take a good look at one!