3 ms·
It's modulating the expression of some important genes; "It is also a selective inhibitor of the human cytochrome P450 isozyme 2D6 (CYP 2D6)" https://www.ncbi
by tudorw 9y ago
It's modulating the expression of some important genes;
"It is also a selective inhibitor of the human cytochrome P450 isozyme 2D6 (CYP 2D6)"
https://www.ncbi.nlm.nih.gov/pubmed/16149329 https://www.ncbi.nlm.nih.gov/pubmed/16149329
"the inhibitions on human liver CYP3A4 and CYP2D6 enzymes by those β-carboline alkaloids were studied kinetically. Harmine, harmol and harmane exhibited noncompetitive inhibition on the activity of CYP3A4 with K(i) values of 16.76, 5.13 and 1.66 μM, respectively. These β-carboline alkaloids were also found to be both substrates and inhibitors for CYP2D6. Harmaline, harmine and harmol showed typical competitive inhibition on the activity of CYP2D6
Inhibition of Human Cytochrome P450 Enzymes 3A4 and 2D6 by β-Carboline Alkaloids, Harmine Derivatives (PDF Download Available). Available from: https://www.researchgate.net/publication/50834428_Inhibition_of_Human_Cytochrome_P450_Enzymes_3A4_and_2D6_by_b-Carboline_Alkaloids_Harmine_Derivatives https://www.researchgate.net/publication/50834428_Inhibition... [accessed Oct 1, 2017]."
https://www.researchgate.net/publication/50834428_Inhibition_of_Human_Cytochrome_P450_Enzymes_3A4_and_2D6_by_b-Carboline_Alkaloids_Harmine_Derivatives https://www.researchgate.net/publication/50834428_Inhibition...
- nnfy 9y agoDo you have evidence that ayuhuasca is mutagenic? Inhibition of enzymes is temporary and generally harmless if you are careful not to consume certain drugs while inhibited.
- tudorw 9y agoNot I, though Dr. Shulgin says; "The second question relates to yet another beta-carboline alkaloid, Harman. This is a structural analogue of Harmine that has been stripped of its methoxyl group. It is widely found in plants and foods, and has been shown in experimental animals to be a vasodilator and a hypotensive agent. It also interacts directly with DNA and is thus a possible mutagenic agent." Courtesy of the wayback machine you can read the article, https://web.archive.org/web/20020325022732/http://www.alchemind.org/shulgin/adsarchive/ayahuasca_maoi.htm https://web.archive.org/web/20020325022732/http://www.alchem...