I take one twice daily, in the morning and the evening. I take regular doses. I haven't noticed becoming acclimated. It is a supplement that I have taken on

I take one twice daily, in the morning and the evening. I take regular doses. I haven't noticed becoming acclimated. It is a supplement that I have taken on and off for a decade or so. I decided to take it again regularly a few years ago, after noticing a tendency toward angry mood swings during a period where I was not taking any supplements at all. After observing this, I thought back on my previous supplement usage, and I recalled having a more even mood when I had been using 5-htp and l-theanine, and decided to try it again to see if it evened things out again. It did, and it continues to do so.