I just posted a slightly more detailed response in this thread related to the layout I use. In terms of how I think it helped: for ergonomics/back pain relief

I just posted a slightly more detailed response in this thread related to the layout I use. In terms of how I think it helped: for ergonomics/back pain relief: I tend to sit up with a lot better posture now rather than 'reaching out to the right' where the traditional mouse used to be. Over time, I'd developed some minor right side back pain and I stretched a lot and attempted better posture. It only helped so much. After I'd switched to the xbox controller, I started to feel better after a few weeks. Months later, the pain was completely gone and it hasn't come back since. I didn't make any other significant changes and I suspect my change in user input devices could be to thank.