The thing is that it would be hard to say that there was a "widespread deficiency in the genome". For the conditions under which we evolved, it's very unlikely

The thing is that it would be hard to say that there was a "widespread deficiency in the genome". For the conditions under which we evolved, it's very unlikely that an always-provigil state is unambiguously better, or that would have become the dominant type. But if the lack of appetite thing is always true, I suppose that could have historically outweighed the cognitive benefits, and now it clearly doesn't. In which case I guess you could call it a deficiency in the genome for current conditions. There might be other, longer term side effects, though.