This means, like me, you have a Valine codon in place of a Methionine codon in your COMT gene at codon 158. This means the enzyme catechol-O-Methyltransferase

This means, like me, you have a Valine codon in place of a Methionine codon in your COMT gene at codon 158. This means the enzyme catechol-O-Methyltransferase which breaks down catecholamines like dopamine/norepinephrine has reduced activity and less stability, resulting in increased catecholamines in some areas of the brain. I recommend downloading your raw data from 23andme and using the prometheus program from SNPedia. This is how I found out about this gene. This program is very raw but includes a lot more research and points you to the relevant papers. Keep in mind, this information is all AFAIK, as I am just browsing this information casually.