Interesting; I've never heard that before. Do you mean that there is peripheral inflammation and the cytokines pass through the blood-brain-barrier, or do you m

Interesting; I've never heard that before. Do you mean that there is peripheral inflammation and the cytokines pass through the blood-brain-barrier, or do you mean that there are actually inflammatory cells that enter the brain and cause depression? Also, can you cite something more specific than a Google search? Most of those are for-profit or interest group websites. Edit: I found an NIH reference: http://www.nimh.nih.gov/science-news/2009/key-molecule-in-inflammation-related-depression-confirmed.shtml http://www.nimh.nih.gov/science-news/2009/key-molecule-in-in... Of the two options I mentioned, it's the former (peripheral inflammation with release of cytokines). Thanks for sharing.