2 ms·
I suppose that does explain the drop off in expression of the gene: Alzheimer's risk of death/year 1-3% [1]. That annual mortality rate is in the right ballpark
by riazrizvi 9y ago
I suppose that does explain the drop off in expression of the gene: Alzheimer's risk of death/year 1-3% [1]. That annual mortality rate is in the right ballpark to explain the frequency of gene expression decrease by about 50% between ages 40 and 80 [2].
Agree the study does look at genes influencing survival rates. I still don't see the link to the headline 'humans are evolving!'. Small second-order effects, okay, sure. So how about, 'Massive Genetic Study shows genetics affect mortality rates, plus maybe there's a small secondary effect on reproduction, who knows?'.
[1]. 83,000 (i) or 3,349 (ii) Alzheimer's deaths per year out of 2mm deaths (iii) => 1-3%
i) http://www.nydailynews.com/life-style/health/alzheimer-kills-previously-thought-study-article-1.1712078 http://www.nydailynews.com/life-style/health/alzheimer-kills...
ii) http://www.alz.org/mglc/in_my_community_60862.asp http://www.alz.org/mglc/in_my_community_60862.asp
iii) https://www.cdc.gov/nchs/fastats/deaths.htm https://www.cdc.gov/nchs/fastats/deaths.htm
[2] See graphs in paper.
- Retric 9y agoPeople over 40+ still have kids. So, there would be a direct link if people started to die at 41.
- mirimir 9y agoI'm confused. Sure, they identified two alleles with occurrence that decreases with age. And sure, that does suggest that those alleles reduce survival rate. But to demonstrate evolutionary change, they'd need data on occurrence of these alleles as a function of birth date, stratified by age. It'll take some time to get such data. Probably at least a few decades.