3 ms·
I had the same reaction as you at first, but read carefully: "Mostafavi and his colleagues tested more than 8 million common mutations, and found two that seem
by perlgeek 9y ago
I had the same reaction as you at first, but read carefully:
"Mostafavi and his colleagues tested more than 8 million common mutations, and found two that seemed to become less prevalent with age"
Old people are less likely to have this gene than young people. This can have two possible explanations: old people with this gene are more likely to are already dead (and thus not show up in the study), or the gene is becoming more prevalent in the younger generations. The statement "People without these mutations have a survival edge and are more likely to live longer" favors the first explanation.
This is not the effect of natural selection on gene prevalence. (And it would be weird for Alzheimer's, which usually occurs at an age where reproduction is often finished, and maybe even raising the kids is done already).
- mannykannot 9y agoMy apologies for editing my reply to add a third paragraph while you were replying to it, but I think that explains the relevance of the age dependence to this study: the decrease in the prevalence with age suggests that they actually do exacerbate the diseases they are associated with, and so the association is not merely a correlation. Note that they are not suggesting these genes have been the subject of selection; it is the hypothesized number of such late-acting genes that were not found that are assumed to have been selected against.