5HTP definitely has therapeutic effects, especially taken sub lingually under the tongue. However, no one should regularly swallow large amounts as it will elev

5HTP definitely has therapeutic effects, especially taken sub lingually under the tongue. However, no one should regularly swallow large amounts as it will elevate free- serotonin levels in your peripheral blood stream, which is very bad for your heart. Increasing serotonin is good in the sense of brain synapses, not bloodstream. You will also build up a tolerance to it and it will stop working. I only use it infrequently as recovery from migraines or drinking. "SAM-e" is S-Adenosyl-methionine and is messing with methylation rather than neurotransmitters directly. It can have very different effects on different people and I believe is generally more dopaminergic than serotogenic and can actually increase anxiety in some people. If you want something 10x as effective as any listed above, look into low-dose 2,5-dimethoxy-4-iodophenethylamine .