7 ms·
Problems with this terrible title: 1. In vitro petri dish testing is a million light years away from showing a compound works in humans. 2. This is a particul
by guyt00 9y ago
Problems with this terrible title:
1. In vitro petri dish testing is a million light years away from showing a compound works in humans.
2. This is a particularly bad problem in brain diseases as getting your compound to cross the blood-brain barrier in correct therapeutic quantities is extremely difficult.
3. We have lots of direct antibodies that kill beta amyloid in vivo that are very advanced in human trials. The problem now is that they often cause micro-damage when removing various forms of amyloid protein or have been shown to be administered far too late when the damage is already done.
4. It's still not clear that beta amyloid is even the main causal agent of Alzheimers!
In general, if you see someone touting a low effort, pre-clinical study as major medical breakthrough, start hitting the downvote button. I'm disappointed this even got to the main page.
- JamesBarney 9y agoYeah over the past few years I've been convinced that beta amyloid is a not a cause of Alzheimer's but a red herring symptom. Too many drugs have failed. Maybe its a disease caused by glial cell dysfunction where beta amyloid is just the most obvious but not most important piece of trash that collects in the brain. And it's just a terrible coincidence injections of beta amyloid have similar effects as Alzheimer's.
- Danihan 9y agoIMO it's neuronal autophagy failing. Plaques accumulating and PH being thrown off are symptoms of that.
- icanhackit 9y agoBased on your hunch do you think the FOX04 peptide, which in mice showed promising results in destroying senescent cells and reducing arterial plaques, might be a solution? https://en.wikipedia.org/wiki/FOXO4 https://en.wikipedia.org/wiki/FOXO4 http://www.sciencemag.org/news/2017/03/molecule-kills-elderly-cells-reduces-signs-aging-mice http://www.sciencemag.org/news/2017/03/molecule-kills-elderl...
- gourou 9y ago> start hitting the downvote button I know this will get downvoted but it's too bad there's no downvote button on HN
- hackinthebochs 9y agodownvoted for irony
- striking 9y agoThat's only true if you have less than 500 karma. Edit: although stories can't be downvoted.
- hannele 9y agoIt's still fun to read about, although acknowledged I have the privilege of not being directly affected by Alzheimer's. It's also really useful when there's comment on Hacker News pointing out the things that have been glossed over in an over-hyped article, so thanks. (no sarcasm intended)
- deleted 9y ago[deleted]
- chillingeffect 9y ago> getting your compound to cross the blood-brain barrier in correct therapeutic quantities is extremely difficult. It's well-established THC crosses the blood brain barrier due to its mental effects. Here are some more evidential links to support this: http://profofpot.com/thc-blood-brain-barrier/ http://profofpot.com/thc-blood-brain-barrier/ http://www.leafscience.com/2013/11/03/harvard-researchers-explain-cannabinoids-protect-brain-hiv/ http://www.leafscience.com/2013/11/03/harvard-researchers-ex... http://www.medic8.com/healthguide/marijuana/marijuana-and-the-brain.html http://www.medic8.com/healthguide/marijuana/marijuana-and-th... http://www.salon.com/2015/02/01/why_smoking_pot_feels_so_good_new_neuroscience_explains_marijuana_and_the_brain/ http://www.salon.com/2015/02/01/why_smoking_pot_feels_so_goo...