Vertical or tilted mice help a lot, and keeping your arm nearly level so you're not bending your wrist a lot. Also, personally I prefer a wider grip mouse for g

Vertical or tilted mice help a lot, and keeping your arm nearly level so you're not bending your wrist a lot. Also, personally I prefer a wider grip mouse for gaming, because I have a tendency to death grip smaller mice, but that's probably only relevant if you game