There's compelling evidence that inflammation can cause insulin resistance and fat accumulation, and that insulin resistance and fat accumulation can further ca

There's compelling evidence that inflammation can cause insulin resistance and fat accumulation, and that insulin resistance and fat accumulation can further cause inflammation. We've found signaling pathways in the body that connect in both directions. So yeah, the causality is actually circular, which in the context of human health implies that a snowball effect is in fact occurring. Escaping this feedback loop is the hard part that we are still working on in the lab.