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Well, imagine inflammation in your circulatory system. So imagine that there's this partical in your blood stream that your immune system responds to. If you ha
by dtawfik1 9y ago
Well, imagine inflammation in your circulatory system. So imagine that there's this partical in your blood stream that your immune system responds to. If you have too many inflammatory responses you could get a blockage. That blockage could lead to a heart attack.
That's one example but these inflammatory responses are also linked to a bunch of diseases. I hope that is a helpful answer.
- dtawfik1 9y agohttps://www.mc.vanderbilt.edu/vanderbiltmedicine/the-good-the-bad-and-the-ugly-of-inflammation/ https://www.mc.vanderbilt.edu/vanderbiltmedicine/the-good-th...
- dtawfik1 9y agoHere's an article the consequences of inflammation on the brain. http://www.dana.org/Publications/ReportOnProgress/Consequences_of_the_Inflamed_Brain/ http://www.dana.org/Publications/ReportOnProgress/Consequenc...
- throw132890123 9y agoNot really, you're now linking the 'inflammation' described in this article to heart attacks. Surely that'd be a bigger story? From the 'article' you linked to: > Obesity and its constant companion, type 2 diabetes, are at epidemic proportions in this country. One thing that connects them is inflammation. How is this not a most blatant case of 'correlation vs causation'? We know the causes of obesity AND type 2 diabetes. Surely inflammation, a cellular immune thing ... is just a correlating factor?
- dtawfik1 9y agohttps://www.uaf.edu/files/olli/OLLI_15_chol_4_red.pdf https://www.uaf.edu/files/olli/OLLI_15_chol_4_red.pdf Checkout slides 7 and 8. My simple understanding is that the sugar creates a particle that provokes an immune response. Cytokines attack the sugar-lipid particle that has been oxidized.
- subcosmos 9y agoGlucose, in high concentration, reacts with proteins at arbitrary locations, effectively gluing them together. This is bad, so the immune system detects this (with a receptor called RAGE) and sends in reinforcements to eat the mess up. https://en.wikipedia.org/wiki/RAGE_(receptor) https://en.wikipedia.org/wiki/RAGE_(receptor)
- subcosmos 9y agoThere's compelling evidence that inflammation can cause insulin resistance and fat accumulation, and that insulin resistance and fat accumulation can further cause inflammation. We've found signaling pathways in the body that connect in both directions. So yeah, the causality is actually circular, which in the context of human health implies that a snowball effect is in fact occurring. Escaping this feedback loop is the hard part that we are still working on in the lab.