2 ms·
IMO one aspect that isn't well understood enough, and not given enough emphasis in research, are the "cleaning" cycles of the brain. In particular, neuronal au
by Danihan 9y ago
IMO one aspect that isn't well understood enough, and not given enough emphasis in research, are the "cleaning" cycles of the brain. In particular, neuronal autophagy, but also cleaning cycles during sleep. If the overall PH is off, something isn't being cleaned correctly. A byproduct isn't being removed.
I'd love to know how a ten day water fast affects the mental processing and bio-markers of a group of schizophrenia patients. I'd also love to compare their brain activity in a sleep study to that of a control group.
Parallel issues here as with most dementias. Plaques seem to form in all brains, but for most people there are cleaning cycles that break them apart and remove them. With Alzheimer's disease this stops happening. Why?
Another intriguing question for schizophrenia -- eating foods rich in glutamate, for instance rich cheeses, is a negative trigger for many people with schizophrenia. Why? Well, glutamate is metabolized in the brain and it's used as a neurotransmitter. Obviously there is some sort of chemical processing issue in some patients. Figure out what exactly what the issue is and I'd bet you'll know much more about the root cause of Schizophrenia, and potentially several other major mental disorders.
https://www.ncbi.nlm.nih.gov/pubmed/25236722 https://www.ncbi.nlm.nih.gov/pubmed/25236722
"Glutamate plays key roles linking carbohydrate and amino acid metabolism via the tricarboxylic acid (TCA) cycle, as well as in nitrogen trafficking and ammonia homeostasis in brain."
"Ammonia homeostasis," sounds like something that might affect PH, right?
- JamesBarney 9y agoWeird thing with glutamate though, is that schizphrenics show lowered activation of glutamate which is supposed to be responsible for the negative symptoms of schizophrenia. Things that increase glutamatergic activity(like cycline) help this.
- loa_in_ 9y agoI think it's a form of bias involving negative feedback loops - since we see mostly patients with symptoms already showing, we see glutamate at the end of the process working to acidize already acidic environment i.e. against the gradient.
- nylonstrung 9y agoAs I understand it the Broad Institute discovered that these 'cleaning' cycles are unchecked and essentially overclocked in schizophrenics
- ceedan 9y agoTen day water fast sounds like a great way to die of a starvation-induced heart attack. What is the significance behind ten days of starvation? Why not 1 or 2 or 3? 10 sounds 100% arbitrary.