4 ms·

Worth reading: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053129/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053129/ > In a study designed to minimize l

Worth reading: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053129/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053129/ > In a study designed to minimize limitations found in many prior investigations, we failed to demonstrate marked residual cognitive effects in ecstasy users. > We found little evidence of decreased cognitive performance in ecstasy users, save for poorer strategic-self-regulation, possibly reflecting increased impulsivity. However this finding might have reflected a premorbid attribute of ecstasy users, rather than a residual neurotoxic effect of the drug. Good news, seems like even in long-term ecstasy users they have good cognition. Edit, also: > MDMA researcher Matthew Baggott: “To the best of my understanding, doses around 1.5-1.7 mg/kg MDMA (roughly 100 to 125 mg MDMA) are unlikely to cause long-lasting serotonin changes. Studies by MAPS have looked for changes in mental abilities after people participated in their studies, with some participants receiving 125 mg followed by 62.5 mg, and have not found any changes.” MAPS study protocol involves 3 - 5 week breaks, and a total of 2 or 3 MDMA sessions in total. https://rollsafe.org/mdma-side-effects/#possible-long-term-side-effects https://rollsafe.org/mdma-side-effects/#possible-long-term-s... And if you want to become an expert and get a summary of all of the safety research, ~1 page of reading here: https://www.mdmawiki.org/wiki/Is_MDMA_Neurotoxic%3F https://www.mdmawiki.org/wiki/Is_MDMA_Neurotoxic%3F

acchow 9y ago
The verdict is still up in the air > Our largely negative findings appear inconsistent with many past studies as well as some more recent investigations (55-57) that report lowered cognitive functions in ecstasy users. Indeed, our findings are inconsistent with several findings in our own pilot study (15)
- phkahler 9y ago
  p-values. They gotta stop relying on p<0.05 which is really a low bar.
- beepboopbeep 9y ago
  Thus why this new approval is such a big deal. We can finally research it and make some scientific conclusions instead of DEA conclusions.
deleted 9y ago
[deleted]
lamontcg 9y ago
Something to keep in mind is that cumulative toxicity is important. The regimens typically used in non-human primates were 5.0mg/kg doses twice daily for 4 days taken subcutaneously instead of orally. A regimen of 2.5mg/kg given orally (p.o.) to Rhesus Monkeys once every 2 weeks for a total of 8 doses over 4 months produced no detectable effect on 5-HT and 5-HIAA levels. Its likely that the monkeys that are seeing neurotoxic effects are taking something like 4-8+ doses at once and doing that twice a day for four days straight. That would fry anyone. https://www.maps.org/news-letters/v05n3/05310neu.html https://www.maps.org/news-letters/v05n3/05310neu.html

acchow 9y ago

The verdict is still up in the air > Our largely negative findings appear inconsistent with many past studies as well as some more recent investigations (55-57) that report lowered cognitive functions in ecstasy users. Indeed, our findings are inconsistent with several findings in our own pilot study (15)

phkahler 9y ago
p-values. They gotta stop relying on p<0.05 which is really a low bar.
beepboopbeep 9y ago
Thus why this new approval is such a big deal. We can finally research it and make some scientific conclusions instead of DEA conclusions.

deleted 9y ago

[deleted]

lamontcg 9y ago

Something to keep in mind is that cumulative toxicity is important. The regimens typically used in non-human primates were 5.0mg/kg doses twice daily for 4 days taken subcutaneously instead of orally. A regimen of 2.5mg/kg given orally (p.o.) to Rhesus Monkeys once every 2 weeks for a total of 8 doses over 4 months produced no detectable effect on 5-HT and 5-HIAA levels. Its likely that the monkeys that are seeing neurotoxic effects are taking something like 4-8+ doses at once and doing that twice a day for four days straight. That would fry anyone. https://www.maps.org/news-letters/v05n3/05310neu.html https://www.maps.org/news-letters/v05n3/05310neu.html