Yes, we get some bounces and vacation/out of office auto-replies but the benefits far outweigh having to delete a few auto-replies that got through the filters.

Yes, we get some bounces and vacation/out of office auto-replies but the benefits far outweigh having to delete a few auto-replies that got through the filters. This has been our experience as well, though maybe it's different for purely B2B communications. We're mostly B2C, and we've never found out-of-office replies to be a significant problem.