Yes, but the software actually needs to be NUMA aware. A lot of current server software works that way - groups of tightly coupled threads target the same node,

Yes, but the software actually needs to be NUMA aware. A lot of current server software works that way - groups of tightly coupled threads target the same node, which prevents major performance issues in multi-CPU systems. In general such systems are very good at multitasking, but not so good at running a single demanding application (if it is not NUMA aware). The same thing applies with Threadripper - albeit with lower internode latency.