It's "funny" how they take all their high quality enzymatic reagents from the company NEB and do this error-repair step (which something NEB has claimed and sho

It's "funny" how they take all their high quality enzymatic reagents from the company NEB and do this error-repair step (which something NEB has claimed and shown that people should be doing with their NGS sample), and whole they use a high fidelity polymerase (Phusion), they don't use the highest fidelity (e.g. NEB Q5 or Kapa HIFI). Also, NEB makes a specific kit to repair NGS samples (i.e. Called pre-CR). Combined this would have translated into a 10-fold lower error rate (so regular NGS 10^-4, this paper 10^-6, then 10^-7 with even better enzymes). Targeted capture using Agilent's SureSelect is pretty common in the cancer field. Their custom implementation allows for oversampling (30,000x) which, along the enzymatic error correction, allows them a high confidence in the target they chose to evaluate. Overall, I think this is neat.