4-AcO-DMT is psilacetin, which is an acetylated form of 4-HO-DMT, or psilocin. Acetylization seems to result in an easier time crossing the blood-brain barrier,

4-AcO-DMT is psilacetin, which is an acetylated form of 4-HO-DMT, or psilocin. Acetylization seems to result in an easier time crossing the blood-brain barrier, resulting in a quicker onset of effects, with a matched quicker comedown. You're still looking at a couple hours. Even without the psilocybin (or other alkaloids present), the experience appears mostly identical to P. cubensis mushrooms, but without the nausea, and seemingly a higher disposition toward producing negative experiences. It's incredibly easy to be overwhelmed by the euphoria being too intense, and dysphoria over negative effects such as akathisia. This can very easily spiral into mild panic attacks, knowing full well that things aren't going to wear off for a few more hours. The milder variants 4-AcO-MET and 4-AcO-DET seem to reduce negative experiences, but overall they're still far too unpredictable whether the experience will end up enjoyable or not. Whether natural or synthetic -- regrettably, the efficacy in treating depression and obsessive compulsive disorder appear to be overly optimistic.