I use some of the unsubscribe options when the sender seems reputable, in other cases I am worried to use it, as perhaps they are just sending out emails to get

I use some of the unsubscribe options when the sender seems reputable, in other cases I am worried to use it, as perhaps they are just sending out emails to get a confirmation that the account is valid so they can then spam it all the more. Our emails go via a host which provides a CPANEL interface, and from there I have a rule for all inboxes which I add to (for deleting spam), on average, once a week. There are probably a few hundred entries on the rule, but overtime it has worked very well. It normally takes me a few moments to add a new entry to the rule list, just because I try to be very careful to ensure I won't delete any important emails.