4 ms·
Indeed, there are a lot of ways mitochondrial dysfunction could lead to depression on a physical level - thyroid function suppression, HPA axis disorder (leadin
by manmal 9y ago
Indeed, there are a lot of ways mitochondrial dysfunction could lead to depression on a physical level - thyroid function suppression, HPA axis disorder (leading again to thyroid suppression), various electrolyte imbalances caused by decreased intestinal uptake (eg magnesium deficiency can cause "untreatable" depression), microbiome shifts due to decreased peristalsis leading to decreased serotonin levels...
- cpncrunch 9y agoTrue, but it seems unlikely that CFS could be caused by the mitochondria or intestinal update suddenly screwing up overnight. A neuropsychiatric disorder caused by chronic stress seems more plausible, with both the fatigue and depression being generated in the brain itself.
- manmal 9y agoMany people describe that their CFS started right after coming down with a virus, so a malfunctioning immune system seems a cofactor. Impaired T cells have been hypothesized..
- cpncrunch 9y agoIf you look at the research (e.g. http://www.sciencedirect.com/science/article/pii/S0022395696000507 http://www.sciencedirect.com/science/article/pii/S0022395696...) most people report a viral infection and stressful events (more people report stress than virus). Bear in mind that infections are physiologically stressful (http://dx.doi.org/10.1089/vim.2005.18.41 http://dx.doi.org/10.1089/vim.2005.18.41) in that they activate the HPA axis in the same way that a psychological stressor does. >a malfunctioning immune system seems a cofactor. Impaired T cells have been hypothesized.. But there has to be a reason for that suddenly happening. And it doesn't explain patients who didn't have a viral infection at onset, or those who don't have ongoing EBV (or other) infections...