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CFS stands for "Chronic Fatigue Syndrome". Syndromes are "a group of symptoms which consistently occur together, or a condition characterized by a set of associ

by zik 9y ago

CFS stands for "Chronic Fatigue Syndrome". Syndromes are "a group of symptoms which consistently occur together, or a condition characterized by a set of associated symptoms". It is literally a description of symptoms (which may have a variety of causes).

tudorw 9y ago
"Neural mechanisms of central sensitization modulate the amplitude of sensory inputs and enhance conscious perception of nociceptive and interoceptive stimuli. Objective biomarkers and mechanisms remain elusive for explaining the disabling fatigue, exertional exhaustion and cognitive incapacitation. R01NS085131." http://www.jacionline.org/article/S0091-6749(16)32198-4/fulltext http://www.jacionline.org/article/S0091-6749(16)32198-4/full... "Conclusion The work supports the assertion that CFS should not be considered to fall within the spectrum of mtDNA disease. However, the current study cannot exclude a role for nuclear genes with a mitochondrial function, nor a role of mtDNA population variants in susceptibility to disease. This study highlights the need for more to be done to understand the pathophysiology of CFS." Clinically proven mtDNA mutations are not common in those with chronic fatigue syndrome. https://bmcmedgenet.biomedcentral.com/articles/10.1186/s12881-017-0387-6 https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288...
- nihy 9y ago
  The absence of mitochondrial DNA mutations known to be associated with disease does not mean it's not a mitochondrial disease (in the sense that mitochondria are abnormal in some way and relevant to the disease). Simply put, it's not a genetic mitochondrial disease. There is a fair amount of evidence that mitochondrial function is abnormal in CFS. See for example this study http://www.pnas.org/content/early/2016/08/24/1607571113.long http://www.pnas.org/content/early/2016/08/24/1607571113.long
  - tudorw 9y ago
    Thanks, I did not intend to indicate it was not a mitochondrial disease or related to mitochondrial function, just that it's not the 'final solution' other posters seem to have implied. It would seem likely that from further research that CFS will be subdivided into smaller groups, with some having clinical tests and causes that have been established, others still eluding a resolution.

by zik 9y ago

tudorw 9y ago

"Neural mechanisms of central sensitization modulate the amplitude of sensory inputs and enhance conscious perception of nociceptive and interoceptive stimuli. Objective biomarkers and mechanisms remain elusive for explaining the disabling fatigue, exertional exhaustion and cognitive incapacitation. R01NS085131." http://www.jacionline.org/article/S0091-6749(16)32198-4/fulltext http://www.jacionline.org/article/S0091-6749(16)32198-4/full... "Conclusion The work supports the assertion that CFS should not be considered to fall within the spectrum of mtDNA disease. However, the current study cannot exclude a role for nuclear genes with a mitochondrial function, nor a role of mtDNA population variants in susceptibility to disease. This study highlights the need for more to be done to understand the pathophysiology of CFS." Clinically proven mtDNA mutations are not common in those with chronic fatigue syndrome. https://bmcmedgenet.biomedcentral.com/articles/10.1186/s12881-017-0387-6 https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288...

nihy 9y ago
The absence of mitochondrial DNA mutations known to be associated with disease does not mean it's not a mitochondrial disease (in the sense that mitochondria are abnormal in some way and relevant to the disease). Simply put, it's not a genetic mitochondrial disease. There is a fair amount of evidence that mitochondrial function is abnormal in CFS. See for example this study http://www.pnas.org/content/early/2016/08/24/1607571113.long http://www.pnas.org/content/early/2016/08/24/1607571113.long
- tudorw 9y ago
  Thanks, I did not intend to indicate it was not a mitochondrial disease or related to mitochondrial function, just that it's not the 'final solution' other posters seem to have implied. It would seem likely that from further research that CFS will be subdivided into smaller groups, with some having clinical tests and causes that have been established, others still eluding a resolution.