indeed, https://www.ncbi.nlm.nih.gov/pubmed/18698000 https://www.ncbi.nlm.nih.gov/pubmed/18698000 The endocannabinoid anandamide is a substrate for the human po

indeed, https://www.ncbi.nlm.nih.gov/pubmed/18698000 https://www.ncbi.nlm.nih.gov/pubmed/18698000 The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. (The discovery of anandamide came from research into CB1 and CB2, as it was inevitable that a naturally occurring (endogenous) chemical would be found to affect these receptors.) Gene's also seem to play a role https://mobile.nytimes.com/2015/03/08/opinion/sunday/the-feel-good-gene.html https://mobile.nytimes.com/2015/03/08/opinion/sunday/the-fee...