4 ms·

Astonishing, how none of these articles and comments seem to mention medical marijuana. The /r/trees subreddit might be filter bubble, but the fact that you're

Astonishing, how none of these articles and comments seem to mention medical marijuana. The /r/trees subreddit might be filter bubble, but the fact that you're able to find individual stories that point at MMJ helping at least some people with Chronic Fatigue Syndrome, seems interesting. Also notice that the patient from this article went to Jamaica and India, two destinations famous for their cannabis. Maybe the patient's endocannabinoid system is off.

tudorw 9y ago
indeed, https://www.ncbi.nlm.nih.gov/pubmed/18698000 https://www.ncbi.nlm.nih.gov/pubmed/18698000 The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. (The discovery of anandamide came from research into CB1 and CB2, as it was inevitable that a naturally occurring (endogenous) chemical would be found to affect these receptors.) Gene's also seem to play a role https://mobile.nytimes.com/2015/03/08/opinion/sunday/the-feel-good-gene.html https://mobile.nytimes.com/2015/03/08/opinion/sunday/the-fee...
DanBC 9y ago
> but the fact that you're able to find individual stories that point at MMJ helping at least some people with Chronic Fatigue Syndrome, seems interesting. No, it's not in any way interesting. You'll always find people saying "this helped me", where "this" is cannabis, homeopathy, crystals, prayer, some type of medication, some type of surgery.
- tudorw 9y ago
  Yes, but the OP reply has a point, anecdotal evidence is often a factor in finding off label uses for pharmaceuticals, so it's worth recording and investigating anecdotal evidence, it's certainly not the basis for ongoing advice, but it is a starting point for possibly worthy research. "When a drug is prescribed off-label, however, the risks may increase. That’s because the safety and efficacy of off-label uses has not been evaluated by the FDA. Instead, off-label use is often based on smaller sample sizes and anecdotal evidence, such as how well a particular doctor sees that an off-label use has worked for her patients in the past. While information like this can seem compelling, the drug hasn’t been put to the same rigorous scientific testing and analysis as it has for its on-label uses. Unexpected side effects can pop up, some of them serious." http://www.rotlaw.com/legal-library/what-is-off-label-use/ http://www.rotlaw.com/legal-library/what-is-off-label-use/

tudorw 9y ago

indeed, https://www.ncbi.nlm.nih.gov/pubmed/18698000 https://www.ncbi.nlm.nih.gov/pubmed/18698000 The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. (The discovery of anandamide came from research into CB1 and CB2, as it was inevitable that a naturally occurring (endogenous) chemical would be found to affect these receptors.) Gene's also seem to play a role https://mobile.nytimes.com/2015/03/08/opinion/sunday/the-feel-good-gene.html https://mobile.nytimes.com/2015/03/08/opinion/sunday/the-fee...

DanBC 9y ago

> but the fact that you're able to find individual stories that point at MMJ helping at least some people with Chronic Fatigue Syndrome, seems interesting. No, it's not in any way interesting. You'll always find people saying "this helped me", where "this" is cannabis, homeopathy, crystals, prayer, some type of medication, some type of surgery.

tudorw 9y ago
Yes, but the OP reply has a point, anecdotal evidence is often a factor in finding off label uses for pharmaceuticals, so it's worth recording and investigating anecdotal evidence, it's certainly not the basis for ongoing advice, but it is a starting point for possibly worthy research. "When a drug is prescribed off-label, however, the risks may increase. That’s because the safety and efficacy of off-label uses has not been evaluated by the FDA. Instead, off-label use is often based on smaller sample sizes and anecdotal evidence, such as how well a particular doctor sees that an off-label use has worked for her patients in the past. While information like this can seem compelling, the drug hasn’t been put to the same rigorous scientific testing and analysis as it has for its on-label uses. Unexpected side effects can pop up, some of them serious." http://www.rotlaw.com/legal-library/what-is-off-label-use/ http://www.rotlaw.com/legal-library/what-is-off-label-use/