Not at all, although there are some similarities at a lower level (First class notion of time). Datomic has a much tighter focus on immutability, auditability,

Not at all, although there are some similarities at a lower level (First class notion of time). Datomic has a much tighter focus on immutability, auditability, and database-as-a-value. Datomic isn't a good fit for use as a general purpose time series db where you have billions of observations.