Let me think. These are for 2.x line, I still haven't tried Python 3.x as it doesn't seem to be significantly leaner and more modern than Python 2.x. I'll go fo

Let me think. These are for 2.x line, I still haven't tried Python 3.x as it doesn't seem to be significantly leaner and more modern than Python 2.x. I'll go for Python 3 no later than when I absolutely have to. 1) Scoping: there's no nested lexical scoping but only function and global scope. Makes many unnecessary workarounds necessary. 2) Read-only closures: you have to use the list hack, you can't just assign to any closed-over vars. 3) No do-while. Surprisingly often needed and thus irritating. 4) Some shortcomings aren't inherent in Python: while I would always like to prefer generators over lists and list comprehensions, and consider iterators elegant, I started considering iterators and itertools as cumbersome and old-fashioned right after I saw lazy sequences in action in Clojure. 5) Various function and method names that I just never, ever recall without first rethinking it again. Like dict.setdefault() which is actually dict.get() but with a default value. There's probably a dozen of these, and each time I just wonder: why is it so difficult to properly rename a few functions and gradually deprecate the old ones. 6) Last, the classical "there are no proper anonymous functions": lambda doesn't cut it and having to specifically name "anonymous" functions is cumbersome. Combined with scoping limitations, even using a generic name like "_" for local functions to be passed as arguments can cause trouble. There used to be more but I have done less and less with Python recently and much more with Clojure, so the irks are fading.