They had a video of playing Unreal Tournament (the new one) on a Talos 1 with a AMD card. As long as a card with Open Source driver support gets used it should

They had a video of playing Unreal Tournament (the new one) on a Talos 1 with a AMD card. As long as a card with Open Source driver support gets used it should work mostly fine. Back then they need a 4line patch to play ut4.