4 ms·

Tissue Nanotransfection

5 points by justintocci 9y ago

Anyone have any real information on this?

justintocci 9y ago
I can see the news items all over but no real information on how it works, what the mechanism is, where the papers have been published, etc https://www.bing.com/search?q=Ohio+State+device+heals+organs&filters=tnTID%3a%228F7CBB53-CA98-4b4d-9FEB-950F12AFB2BD%22+tnVersion%3a%222068690%22+segment%3a%22popularnow.carousel%22+tnCol%3a%220%22+tnOrder%3a%22e803ea85-5b48-48d8-bcac-86e4c90c56ce%22&FORM=CNTPNH https://www.bing.com/search?q=Ohio+State+device+heals+organs...
- sp332 9y ago
  You can edit your original comment for up to two hours. You don't have to make a new comment for each update.
justintocci 9y ago
https://www.theengineer.co.uk/tnt-tissue-regeneration/ https://www.theengineer.co.uk/tnt-tissue-regeneration/ this gives better info of how it works but still no paper
- 162256 9y ago
  see supplemental data - https://images.nature.com/full/nature-assets/nnano/journal/vaop/ncurrent/extref/nnano.2017.134-s1.pdf https://images.nature.com/full/nature-assets/nnano/journal/v...
justintocci 9y ago
Ok, paper supposedly published here but searching finds no articles http://www.nature.com/nnano/index.html http://www.nature.com/nnano/index.html
- CatMtKing 9y ago
  I think it's this one https://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2017.134.html https://www.nature.com/nnano/journal/vaop/ncurrent/full/nnan...
  - prefect42 9y ago
    ...which has reference #14 has Sen listed as the author of another article (can't find direct link), here's #14 though: Sen, C. K. & Ghatak, S. miRNA control of tissue repair and regeneration. Am. J. Pathol. 185, 2629–2640 (2015).
cakra 9y ago
It looks like it is being advanced as a proprietary technology and they don't want to publish on the mechanism until it is commercialized. However there is a patent http://www.google.com.pg/patents/WO2010012077A1?cl=en http://www.google.com.pg/patents/WO2010012077A1?cl=en
- 162256 9y ago
  I don't believe that patent is the relevant one.
162256 9y ago
here are the supplemental data that have been released as "Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue" http://www.nature.com/nnano/journal/vaop/ncurrent/extref/nnano.2017.134-s1.pdf http://www.nature.com/nnano/journal/vaop/ncurrent/extref/nna...
162256 9y ago
they used "projection lithography, contact photolithography, and deep reactive ion etching –DRIE- to fabricate silicon-based TNT devices. not clear what's proprietary.
pimmdphd 9y ago
Knowing a little inside info about this development I must add a big word of caution on this science. It may be possible to add this type of coding in an optical format, in short the code may be able to be added say to a video and when someone watches the video the optical tissues in their eyes and retina may begin to transfer into whatever form of tissue is coded. This may indeed be able to effect brain tissue by this route of administration and that is terrifying!
- Logicwax 9y ago
  Doesn't this require a physical package of some sort of bio material to be delivered to the cell, with electricity being used to open the cell membranes and push it through via ions? If I'm understanding that correctly, then how do you make the leap to optical-only transfer? It's almost as if you're claiming that an optical signal could somehow cause a buffer-overflow exploit in the cone/rod cells of a human eye, and then root the cell's "kernel" and start making run-time patches. And that sounds like a completely different scientific breakthrough than what this TNT stuff sounds like. could you elaborate any further?
  - Pardisheny 9y ago
    Does sound interesting tho, just extrapolating but light/photons do contain energy and hence may just be able to initiate such an action. May depend on the type of display being used .
joonisboss 9y ago
So I was curious about this and read the supplemental pdf, thank you justintocci. The technology hinges on Nanochannel Electroporation as the storage and delivery vehicle for the DNA. Found the following paper (scrapped the url from Wiley) that goes into detail. The potential here is insane! Joined Hacker News just to share it. :) http://onlinelibrary.wiley.com/store/10.1002/advs.201500111/asset/advs201500111.pdf?v=1&t=j63yp6z9&s=fcce8c62c7a4f0c0792b162e1abcebf55c0edb7e http://onlinelibrary.wiley.com/store/10.1002/advs.201500111/...
grayzilla 9y ago
David Langford had a really great FAQ about this technology over on the comp.basilisk FAQ newsgroup: http://ansible.uk/writing/c-b-faq.html http://ansible.uk/writing/c-b-faq.html

5 points by justintocci 9y ago

Anyone have any real information on this?

I can see the news items all over but no real information on how it works, what the mechanism is, where the papers have been published, etc https://www.bing.com/search?q=Ohio+State+device+heals+organs&filters=tnTID%3a%228F7CBB53-CA98-4b4d-9FEB-950F12AFB2BD%22+tnVersion%3a%222068690%22+segment%3a%22popularnow.carousel%22+tnCol%3a%220%22+tnOrder%3a%22e803ea85-5b48-48d8-bcac-86e4c90c56ce%22&FORM=CNTPNH https://www.bing.com/search?q=Ohio+State+device+heals+organs...

sp332 9y ago
You can edit your original comment for up to two hours. You don't have to make a new comment for each update.

justintocci 9y ago

https://www.theengineer.co.uk/tnt-tissue-regeneration/ https://www.theengineer.co.uk/tnt-tissue-regeneration/ this gives better info of how it works but still no paper

162256 9y ago
see supplemental data - https://images.nature.com/full/nature-assets/nnano/journal/vaop/ncurrent/extref/nnano.2017.134-s1.pdf https://images.nature.com/full/nature-assets/nnano/journal/v...

justintocci 9y ago

Ok, paper supposedly published here but searching finds no articles http://www.nature.com/nnano/index.html http://www.nature.com/nnano/index.html

CatMtKing 9y ago
I think it's this one https://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2017.134.html https://www.nature.com/nnano/journal/vaop/ncurrent/full/nnan...
- prefect42 9y ago
  ...which has reference #14 has Sen listed as the author of another article (can't find direct link), here's #14 though: Sen, C. K. & Ghatak, S. miRNA control of tissue repair and regeneration. Am. J. Pathol. 185, 2629–2640 (2015).

cakra 9y ago

It looks like it is being advanced as a proprietary technology and they don't want to publish on the mechanism until it is commercialized. However there is a patent http://www.google.com.pg/patents/WO2010012077A1?cl=en http://www.google.com.pg/patents/WO2010012077A1?cl=en

162256 9y ago
I don't believe that patent is the relevant one.

162256 9y ago

here are the supplemental data that have been released as "Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue" http://www.nature.com/nnano/journal/vaop/ncurrent/extref/nnano.2017.134-s1.pdf http://www.nature.com/nnano/journal/vaop/ncurrent/extref/nna...

162256 9y ago

they used "projection lithography, contact photolithography, and deep reactive ion etching –DRIE- to fabricate silicon-based TNT devices. not clear what's proprietary.

pimmdphd 9y ago

Knowing a little inside info about this development I must add a big word of caution on this science. It may be possible to add this type of coding in an optical format, in short the code may be able to be added say to a video and when someone watches the video the optical tissues in their eyes and retina may begin to transfer into whatever form of tissue is coded. This may indeed be able to effect brain tissue by this route of administration and that is terrifying!

Logicwax 9y ago
Doesn't this require a physical package of some sort of bio material to be delivered to the cell, with electricity being used to open the cell membranes and push it through via ions? If I'm understanding that correctly, then how do you make the leap to optical-only transfer? It's almost as if you're claiming that an optical signal could somehow cause a buffer-overflow exploit in the cone/rod cells of a human eye, and then root the cell's "kernel" and start making run-time patches. And that sounds like a completely different scientific breakthrough than what this TNT stuff sounds like. could you elaborate any further?
- Pardisheny 9y ago
  Does sound interesting tho, just extrapolating but light/photons do contain energy and hence may just be able to initiate such an action. May depend on the type of display being used .

joonisboss 9y ago

So I was curious about this and read the supplemental pdf, thank you justintocci. The technology hinges on Nanochannel Electroporation as the storage and delivery vehicle for the DNA. Found the following paper (scrapped the url from Wiley) that goes into detail. The potential here is insane! Joined Hacker News just to share it. :) http://onlinelibrary.wiley.com/store/10.1002/advs.201500111/asset/advs201500111.pdf?v=1&t=j63yp6z9&s=fcce8c62c7a4f0c0792b162e1abcebf55c0edb7e http://onlinelibrary.wiley.com/store/10.1002/advs.201500111/...

grayzilla 9y ago

David Langford had a really great FAQ about this technology over on the comp.basilisk FAQ newsgroup: http://ansible.uk/writing/c-b-faq.html http://ansible.uk/writing/c-b-faq.html