3 ms·
Anybody read the words sensitivity, specificity, or gold standard? Just because it doesn't show up on PET doesn't mean squat if PET has a low sensitivity.
by jiggunjer 9y ago
Anybody read the words sensitivity, specificity, or gold standard? Just because it doesn't show up on PET doesn't mean squat if PET has a low sensitivity.
- AstralStorm 9y agoSo what's the gold standard of detecting Alzheimer's? (It is a rhetorical question.)
- seesomesense 9y agoBrain cutting and histopathology See http://www.bu.edu/alzresearch/brain-cutting-636x433/ http://www.bu.edu/alzresearch/brain-cutting-636x433/ "one of a variety of silver impregnation staining techniques, such as the modified Bielschowski or Gallyas technique, or the fluorochrome dye thioflavin S is typically employed to visualize neurofibrillary tangles Because these techniques require either specialized equipment (the thioflavin S stain requires the use of a fluorescence microscope with specialized excitatory and barrier filters) or experienced histotechnologists (in the case of silver impregnation stains), most anatomic pathologists in general practice lack the capability to properly evaluate brain specimens submitted for the diagnosis of Alzheimer's disease. Such specimens are best referred to specialized neuropathology laboratories where the necessary experience and facilities are in place."