You do the same thing, over and over again. If you look at some of the most successful businessmen in history, you'll see that a lot of what they did was find

You do the same thing, over and over again. If you look at some of the most successful businessmen in history, you'll see that a lot of what they did was find some kind of unexploited area of the market and take advantage of it. Usually it starts in their home town, but it can often by replicated and expanded outside of that area. And when they do that they generally get to take advantage of the economies of scale. Along the way, if they iterate and refine on the process -- they get stronger and stronger till they become the $50B MNC you're talking about. Looking at the history of UPS, this seems pretty apparent. They started doing deliveries in Seattle > California > West Coast > New York > East Coast > Midwest > Canada > Europe. Walmart and McDonalds kind of did the same thing. In every instance there is a certain level of innovation that keeps them ahead of the pack.