There's a hack to sort-of disable the keybind: Go to chrome://extensions/ and open "Keyboard Shortcuts" (bottom right). Pick an extension you don't use anymore

There's a hack to sort-of disable the keybind: Go to chrome://extensions/ and open "Keyboard Shortcuts" (bottom right). Pick an extension you don't use anymore (or install one), and set the shortcut for "Activate the extension" to cmd+q or ctrl+shift+q.