No, I was using make to process large files for bioinformatics. So, think 60GB (compressed) of sequencing data from a whole genome sequencing run, which comes a

No, I was using make to process large files for bioinformatics. So, think 60GB (compressed) of sequencing data from a whole genome sequencing run, which comes as a set of ~800,000,000 individually sequenced short stretches of DNA in two files. A multi-threaded process converts that into a file containing the sequences and where they align in the human genome, and takes about a day. Once that job has been finished, other jobs can be kicked off to use the produced data. Overall, the build process is a DAG with several hundred individual jobs, and performing that in a make-like system helps it to be managed effectively. Just not make itself.