4 ms·
I did my undergrad in biophysics and this is basically a simplified version of the currently accepted view. We now also know that some proteins fold in units, a
by tstactplsignore 9y ago
I did my undergrad in biophysics and this is basically a simplified version of the currently accepted view. We now also know that some proteins fold in units, and can have multiple stable fold stopping points along the folding paths, and a good deal of proteins never really have a single stable fold at all. Basically google scholar "protein folding energy landscape" for more details.
http://m.pnas.org/content/113/12/3159.short http://m.pnas.org/content/113/12/3159.short
Here's a nice visualization:
https://www.researchgate.net/profile/Manajit_Hayer-Hartl/publication/26262477/figure/fig3/AS:272608570638341@1442006356158/Figure-1-Energy-landscape-scheme-of-protein-folding-and-aggregationThe-purple-surface.png https://www.researchgate.net/profile/Manajit_Hayer-Hartl/pub...