6 ms·

What are you going on about? Vibrations or something? What does that have to do with this article, about how mathematicians helped solve the minimal genetic inf

What are you going on about? Vibrations or something? What does that have to do with this article, about how mathematicians helped solve the minimal genetic information necessary to fit inside of, and encode for, the construction of ostensibly complex geometric structures of viral capsids.

tinix 9y ago
I don't know how to make it much simpler, but I'll try to ELI5 for you. Geometry has a direct relationship to resonance[0]. If you can target the specific resonance frequency of the capsid, you can destroy it with a wave form. If you break the capsid, the virus will not survive. Resonance can be induced in many ways, such as with ultrasound[1], microwaves[2], magnetic/dielectric fields[3], light[4][5], etc... Obviously, this isn't fool-proof, as resonance can also actually assist viruses with permeating cell membranes[6]. However, these concepts can be applied to many areas of biosciences. We know magnetic fields can also disrupt cancer[7]. [0]https://www.nature.com/articles/srep18030 https://www.nature.com/articles/srep18030 Resonances in Physics and Geometry [1] http://pubmedcentralcanada.ca/pmcc/articles/PMC183525/pdf/aem00060-0219.pdf http://pubmedcentralcanada.ca/pmcc/articles/PMC183525/pdf/ae... Quantitative Assessment of the Germicidal Efficacy of Ultrasonic Energy [2] http://www.ams.org/notices/199903/zworski.pdf http://www.ams.org/notices/199903/zworski.pdf Efficient Structure Resonance Energy Transfer from Microwaves to Confined Acoustic Vibrations in Viruses [3] https://www.google.com/patents/US4524079 https://www.google.com/patents/US4524079 Deactivation of microorganisms by an oscillating magnetic field [4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171215/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171215/ Ultrashort pulsed laser treatment inactivates viruses by inhibiting viral replication and transcription in the host nucleus [5] https://asu.pure.elsevier.com/en/publications/selective-inactivation-of-human-immunodeficiency-virus-with-an-ul https://asu.pure.elsevier.com/en/publications/selective-inac... Selective destruction of viruses with ultrashort pulsed lasers [6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189159/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189159/ Effect of ultrasound on herpes simplex virus infection in cell culture [7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155400/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155400/ Effect of Magnetic Fields on Tumor Growth and Viability
- tinix 9y ago
  Sorry, I can't edit my post now, and I just realized I copied the wrong link for that first reference: [0] http://www.ams.org/notices/199903/zworski.pdf http://www.ams.org/notices/199903/zworski.pdf Resonances in Physics and Geometry Anyway, to further elaborate... If we know how specific RNA in viri build their capsid shells, then we can theoretically compute the specific resonant frequencies of different viri by sequencing their DNA/RNA etc... It's all connected, you see. Further, we know that viri can cause cells to become cancerous through RNA/DNA mutation[8][9]. My point is, killing viruses in your body by means of resonance COULD feasibly assist with curing cancer, or at least, can prevent it from spreading. Obviously it has nothing to do with metastasizing cells, but it can prevent more viri from giving more cells bad mutations. [8] https://www.ncbi.nlm.nih.gov/pubmed/6891372 https://www.ncbi.nlm.nih.gov/pubmed/6891372 Viral mechanisms of carcinogenesis. [9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185770/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185770/ Cell Transformation by RNA Viruses: An Overview

tinix 9y ago

I don't know how to make it much simpler, but I'll try to ELI5 for you. Geometry has a direct relationship to resonance[0]. If you can target the specific resonance frequency of the capsid, you can destroy it with a wave form. If you break the capsid, the virus will not survive. Resonance can be induced in many ways, such as with ultrasound[1], microwaves[2], magnetic/dielectric fields[3], light[4][5], etc... Obviously, this isn't fool-proof, as resonance can also actually assist viruses with permeating cell membranes[6]. However, these concepts can be applied to many areas of biosciences. We know magnetic fields can also disrupt cancer[7]. [0]https://www.nature.com/articles/srep18030 https://www.nature.com/articles/srep18030 Resonances in Physics and Geometry [1] http://pubmedcentralcanada.ca/pmcc/articles/PMC183525/pdf/aem00060-0219.pdf http://pubmedcentralcanada.ca/pmcc/articles/PMC183525/pdf/ae... Quantitative Assessment of the Germicidal Efficacy of Ultrasonic Energy [2] http://www.ams.org/notices/199903/zworski.pdf http://www.ams.org/notices/199903/zworski.pdf Efficient Structure Resonance Energy Transfer from Microwaves to Confined Acoustic Vibrations in Viruses [3] https://www.google.com/patents/US4524079 https://www.google.com/patents/US4524079 Deactivation of microorganisms by an oscillating magnetic field [4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171215/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171215/ Ultrashort pulsed laser treatment inactivates viruses by inhibiting viral replication and transcription in the host nucleus [5] https://asu.pure.elsevier.com/en/publications/selective-inactivation-of-human-immunodeficiency-virus-with-an-ul https://asu.pure.elsevier.com/en/publications/selective-inac... Selective destruction of viruses with ultrashort pulsed lasers [6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189159/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189159/ Effect of ultrasound on herpes simplex virus infection in cell culture [7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155400/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155400/ Effect of Magnetic Fields on Tumor Growth and Viability

tinix 9y ago
Sorry, I can't edit my post now, and I just realized I copied the wrong link for that first reference: [0] http://www.ams.org/notices/199903/zworski.pdf http://www.ams.org/notices/199903/zworski.pdf Resonances in Physics and Geometry Anyway, to further elaborate... If we know how specific RNA in viri build their capsid shells, then we can theoretically compute the specific resonant frequencies of different viri by sequencing their DNA/RNA etc... It's all connected, you see. Further, we know that viri can cause cells to become cancerous through RNA/DNA mutation[8][9]. My point is, killing viruses in your body by means of resonance COULD feasibly assist with curing cancer, or at least, can prevent it from spreading. Obviously it has nothing to do with metastasizing cells, but it can prevent more viri from giving more cells bad mutations. [8] https://www.ncbi.nlm.nih.gov/pubmed/6891372 https://www.ncbi.nlm.nih.gov/pubmed/6891372 Viral mechanisms of carcinogenesis. [9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185770/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185770/ Cell Transformation by RNA Viruses: An Overview